This package performs linear iv vitro in vivo correlation of linear level A. It provides numerical convolution/deconvolution procedures with unequal time steps and no assumptions about the function shapes.
This is the major function to be called where numerical convolution ad/or deconvolution might be used for a linear in vitro in vivo correlation level A. It performes either numerical convolution via /codeNumConv() or deconvolution via /codeNumDeconv() and correlates their results with the known.data object via linear regression lm(). If you just want raw results of convolution/deconvolution then call explicitely NumConv or link{NumDeconv}
● Data Source:
CranContrib
● Keywords: IVIVC Level A, RivivcA
● Alias: RivivcA
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Numerical deconvolution method based on the convolution and the optim() BFGS method to find in vivo absorption profile through the convolution approach. The function works iteratively with the cumulative in vivo absorption profile optimization performed by the BFGS method in regard to the convolved PK profile and its proximity to the real known p.o. profile.
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