This package provides functions for testing for differential expression for digital data (e.g. RNA-Seq, CAGE-Seq, ChIP-Seq, etc.). Exact unconditional tests based on the negative binomial distribution are provided. Similar functionality exists in the Bioconductor package edgeR where a similar but conditional exact test is implemented. The unconditional test is more powerful, especially for lowly expressed genes or when sample size is extremely small.
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