Design and Analysis of dose-finding studies

Description

The crossdes package provides functions for the construction of of carryover balanced crossover designs. In addition contains functions to check given designs for balance.

Details

The main functions are:
get.plan: Menu-driven selection of crossover designs
allcombs: Construct crossover design with all possible treatment orders
williams: Construct a Williams design
williams.BIB: Construct a crossover design based on a combination of balanced incomplete block designs and Williams designs.
des.MOLS: Construct crossover design based on mutually orthogonal Latin Squares
balmin.RMD: Construct balanced minimal repeated measurements crossover design
isCbalanced: Check whether a crossover design is balanced for first order carryover effects
isGYD: Check whether a crossover design is balanced

Author(s)

Martin Oliver Sailer

References

Earlier version of the package:
Sailer, O. (2005): crossdes: A package for design and randomization in crossover studies. Rnews 5/2, 24-27.

Overview on cross-over designs:
Jones, B. and Kenward, M.G. (1989): Design and Analysis of Cross-Over Trials. Chapman and Hall, London.

Wakeling, I.N. and MacFie, H.J.H. (1995): Designing consumer trials balanced for first and higher orders of carry-over effect when only a subset of k samples from t may be tested. Food Quality and Preference 6, 299-308.

Results