Detect differential binding sites for ChIP sequencing data

Description

ChIPComp is an R library performing the differential binding analysis for ChIP-seq count data. Compared with other similar packages (DBChIP, DIME), ChIPComp considers the control samples in the process of detecting the differential binding sites. Extensive simulation results showed that ChIPComp performs favorably compared to DBChIP and DIME when the control samples are ignored. ChIPComp only works for two group comparison at this time, that is, to detect the differential binding sites for one transcription factor(histone) between two conditions (cell lines). We plan to extend the functionalities and make it work for more general experimental designs in the near future.

Author(s)

Hao Wu <hao.wu@emory.edu>, Li Chen <li.chen@emory.edu>

Results