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Last data update: 2014.03.03

R: Estimation of main effects

HD2013SGImaineffects

R Documentation

Estimation of main effects

A function to estimate main effects (single knock-down effects) in genetic interaction screens.

HD2013SGImaineffects(x, TP, TargetNeg, QueryNeg, eps = 1e-04, maxiter = 100, na.rm = TRUE)

`x`	Two dimensional array.
`TP`	Assignment of target genes to target plates. Used to compute target main effects for each target plate separately.
`TargetNeg`	Negative controls within the set of target genes.
`QueryNeg`	Negative controls within the set of query genes.
`eps`	real number greater than 0. A tolerance for convergence.
`maxiter`	the maximum number of iterations
`na.rm`	logical. Should missing values be removed?

`neg`	Effect of the negative control.
`targetMainEffect`	target main effects
`queryMainEffect`	query main effects
`pi`	Pairwise interaction scores (pi-scores)

changes applied by Bernd Fischer to the implementation of R stats functionmedpolish

Laufer, Fischer et al., 2013