The colorectal dataset is an object of class aCGH. It
represents a collection of 124 array CGH profiles of primary
colorectal tumors and their derived attributes. Each sample was
measured on the BAC clone DNA microarray with approximate resolution
of 1.4 Mb per clone. There were approximately 2400 clones spotted on
the array and each clone was printed in triplicates located
immediately next to each other. Each array consisted of the 16 (4 by
4) subarrays. The clones were mapped on the July 03 UCSC freeze. There
were a number of the discrete and continious phenotypes associated
with the samples such as age, mutation status for various markers,
stage, location and so on. All images were quantified and
normalized by Dr. Taku Tokuyasu using custom image software SPOT and
postprocessing custom software SPROC.
Usage
data(colorectal)
Source
These data were generated at Dr. Fred Waldman's lab at UCSF Cancer
Center by K. Nakao and K. Mehta. The manuscript describing the data
and the analysis are described in
High-resolution analysis of DNA copy number alterations in colorectal
cancer by array-based comparative genomic hybridization,
Carcinogenesis, 2004, Nakao et. al.
References
Nakao et. al., High-resolution analysis of DNA copy number
alterations in colorectal cancer by array-based comparative genomic
hybridization, Carcinogenesis, 2004
Jain et. al, Fully automatic quantification of microarray image data,
Genome Research, 2003
See Also
aCGHplotGenome
Examples
data(colorectal)
## WARNING: plotting the heatmap takes some time
plot(colorectal)
plotGenome(colorectal[,1:2])
Results
R version 3.3.1 (2016-06-21) -- "Bug in Your Hair"
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Platform: x86_64-pc-linux-gnu (64-bit)
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Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.
Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
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> library(aCGH)
Loading required package: cluster
Loading required package: survival
Loading required package: multtest
Loading required package: BiocGenerics
Loading required package: parallel
Attaching package: 'BiocGenerics'
The following objects are masked from 'package:parallel':
clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
clusterExport, clusterMap, parApply, parCapply, parLapply,
parLapplyLB, parRapply, parSapply, parSapplyLB
The following objects are masked from 'package:stats':
IQR, mad, xtabs
The following objects are masked from 'package:base':
Filter, Find, Map, Position, Reduce, anyDuplicated, append,
as.data.frame, cbind, colnames, do.call, duplicated, eval, evalq,
get, grep, grepl, intersect, is.unsorted, lapply, lengths, mapply,
match, mget, order, paste, pmax, pmax.int, pmin, pmin.int, rank,
rbind, rownames, sapply, setdiff, sort, table, tapply, union,
unique, unsplit
Loading required package: Biobase
Welcome to Bioconductor
Vignettes contain introductory material; view with
'browseVignettes()'. To cite Bioconductor, see
'citation("Biobase")', and for packages 'citation("pkgname")'.
Attaching package: 'aCGH'
The following object is masked from 'package:stats':
heatmap
> png(filename="/home/ddbj/snapshot/RGM3/R_BC/result/aCGH/colorectal.Rd_%03d_medium.png", width=480, height=480)
> ### Name: colorectal
> ### Title: Colorectal array CGH dataset
> ### Aliases: colorectal clones.info.ex log2.ratios.ex pheno.type.ex
> ### Keywords: datasets
>
> ### ** Examples
>
>
> data(colorectal)
> ## WARNING: plotting the heatmap takes some time
> plot(colorectal)
> plotGenome(colorectal[,1:2])
Warning message:
In `[.aCGH`(colorectal, , 1:2) : subsetting the log2.ratios only
>
>
>
>
>
>
> dev.off()
null device
1
>