Last data update: 2014.03.03

R: CNV.detailplot_wrap
CNV.detailplot_wrapR Documentation

CNV.detailplot_wrap

Description

Create CNV plot for all detail regions.

Usage

CNV.detailplot_wrap(object, ...)

## S4 method for signature 'CNV.analysis'
CNV.detailplot_wrap(object, set_par = TRUE,
  main = NULL, ...)

Arguments

object

CNV.analysis object.

...

Additional paramters supplied to CNV.detailplot.

set_par

logical. Use recommended graphical parameters for oma and mar? Defaults to TRUE. Original parameters are restored afterwards.

main

character. Title of the plot. Defaults to sample name.

Details

This method is a wrapper of the CNV.detailplot method to plot all detail regions.

Value

NULL.

Author(s)

Volker Hovestadt conumee@hovestadt.bio

Examples

# prepare
library(minfiData)
data(MsetEx)
d <- CNV.load(MsetEx)
data(detail_regions)
anno <- CNV.create_anno(detail_regions = detail_regions)

# create/modify object
x <- CNV.segment(CNV.detail(CNV.bin(CNV.fit(query = d['GroupB_1'],
    ref = d[c('GroupA_1', 'GroupA_2', 'GroupA_3')], anno))))

# output plots
CNV.genomeplot(x)
CNV.genomeplot(x, chr = 'chr6')
CNV.detailplot(x, name = 'PTEN')
CNV.detailplot_wrap(x)

# output text files
CNV.write(x, what = 'segments')
CNV.write(x, what = 'detail')
CNV.write(x, what = 'bins')
CNV.write(x, what = 'probes')

Results


R version 3.3.1 (2016-06-21) -- "Bug in Your Hair"
Copyright (C) 2016 The R Foundation for Statistical Computing
Platform: x86_64-pc-linux-gnu (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> library(conumee)
Loading required package: minfi
Loading required package: BiocGenerics
Loading required package: parallel

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:parallel':

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
    clusterExport, clusterMap, parApply, parCapply, parLapply,
    parLapplyLB, parRapply, parSapply, parSapplyLB

The following objects are masked from 'package:stats':

    IQR, mad, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, cbind, colnames, do.call, duplicated, eval, evalq,
    get, grep, grepl, intersect, is.unsorted, lapply, lengths, mapply,
    match, mget, order, paste, pmax, pmax.int, pmin, pmin.int, rank,
    rbind, rownames, sapply, setdiff, sort, table, tapply, union,
    unique, unsplit

Loading required package: Biobase
Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

Loading required package: lattice
Loading required package: GenomicRanges
Loading required package: S4Vectors
Loading required package: stats4

Attaching package: 'S4Vectors'

The following objects are masked from 'package:base':

    colMeans, colSums, expand.grid, rowMeans, rowSums

Loading required package: IRanges
Loading required package: GenomeInfoDb
Loading required package: SummarizedExperiment
Loading required package: Biostrings
Loading required package: XVector
Loading required package: bumphunter
Loading required package: foreach
Loading required package: iterators
Loading required package: locfit
locfit 1.5-9.1 	 2013-03-22
Setting options('download.file.method.GEOquery'='auto')
Setting options('GEOquery.inmemory.gpl'=FALSE)
Loading required package: IlluminaHumanMethylation450kmanifest
Loading required package: IlluminaHumanMethylation450kanno.ilmn12.hg19
> png(filename="/home/ddbj/snapshot/RGM3/R_BC/result/conumee/CNV.detailplot_wrap.Rd_%03d_medium.png", width=480, height=480)
> ### Name: CNV.detailplot_wrap
> ### Title: CNV.detailplot_wrap
> ### Aliases: CNV.detailplot_wrap CNV.detailplot_wrap,CNV.analysis-method
> 
> ### ** Examples
> 
> # prepare
> library(minfiData)
> data(MsetEx)
> d <- CNV.load(MsetEx)
> data(detail_regions)
> anno <- CNV.create_anno(detail_regions = detail_regions)
using genome annotations from UCSC
getting 450k annotations
 - 470870 probes used
importing regions for detailed analysis
creating bins
 - 53918 bins created
merging bins
 - 15833 bins remaining
> 
> # create/modify object
> x <- CNV.segment(CNV.detail(CNV.bin(CNV.fit(query = d['GroupB_1'],
+     ref = d[c('GroupA_1', 'GroupA_2', 'GroupA_3')], anno))))
> 
> # output plots
> CNV.genomeplot(x)
> CNV.genomeplot(x, chr = 'chr6')
> CNV.detailplot(x, name = 'PTEN')
> CNV.detailplot_wrap(x)
> 
> # output text files
> CNV.write(x, what = 'segments')
         ID chrom loc.start   loc.end num.mark     bstat          pval seg.mean
1  GroupB_1  chr1    635684 249195311     1593        NA            NA   -0.122
2  GroupB_1 chr10    105000 135462374      840        NA            NA   -0.058
3  GroupB_1 chr11    130000  48550000      319  7.851693  4.823678e-13    0.042
4  GroupB_1 chr11  48975000  56675000       15 12.294071  1.649339e-32   -0.091
5  GroupB_1 chr11  56975000  81250000      268 29.745363 9.783071e-192    0.057
6  GroupB_1 chr11  82500000 134873258      312        NA            NA    0.199
7  GroupB_1 chr12    172870  54975000      351 11.507897  2.178154e-28    0.011
8  GroupB_1 chr12  55175000  56075000        5  8.018864  1.507192e-13   -0.178
9  GroupB_1 chr12  56125000 133770948      492        NA            NA   -0.064
10 GroupB_1 chr13  19110000  19525000        3  5.415424  4.913394e-06    0.119
11 GroupB_1 chr13  19725000 114025000      415  9.565066  1.824189e-19    0.348
12 GroupB_1 chr13 114075000 115079939       13        NA            NA    0.151
13 GroupB_1 chr14  19325000 107119770      528        NA            NA   -0.197
14 GroupB_1 chr15  20225000 102410696      571        NA            NA   -0.189
15 GroupB_1 chr16    105000  90222377      624        NA            NA    0.114
16 GroupB_1 chr17     25000   3875000       59 16.221715  8.901516e-57   -0.015
17 GroupB_1 chr17   3925000  38850000      317  7.820936  6.065279e-13   -0.160
18 GroupB_1 chr17  38925000  39400000        8 16.150879  3.079978e-56   -0.345
19 GroupB_1 chr17  39475000  81122605      430        NA            NA   -0.053
20 GroupB_1 chr18     80000  21125000       81 21.391647  3.413057e-99   -0.031
21 GroupB_1 chr18  21375000  77983624      162        NA            NA   -0.364
22 GroupB_1 chr19    180000  59084492      711        NA            NA    0.050
23 GroupB_1  chr2    130000 243026238     1282        NA            NA   -0.027
24 GroupB_1 chr20    155000   8725000       65 13.487427  3.902028e-39    0.154
25 GroupB_1 chr20   9475000  62907760      294        NA            NA    0.297
26 GroupB_1 chr21  10848948  31025000       27  5.747398  2.031374e-07   -0.073
27 GroupB_1 chr21  31525000  32125000        5  8.799096  1.101514e-16   -0.269
28 GroupB_1 chr21  32575000  48084948      125        NA            NA   -0.032
29 GroupB_1 chr22  16373925  51222283      300        NA            NA   -0.122
30 GroupB_1  chr3    155000  60150000      362 18.594996  1.060849e-74    0.056
31 GroupB_1  chr3  60850000  73675000       64 18.946425  1.813659e-77    0.215
32 GroupB_1  chr3  74175000 197831215      552        NA            NA    0.035
33 GroupB_1  chr4     55000  10475000      136 14.363704  2.842430e-44   -0.125
34 GroupB_1  chr4  10925000 190972138      606        NA            NA   -0.253
35 GroupB_1  chr5     55000 162925000      709 15.310711  2.214461e-50   -0.046
36 GroupB_1  chr5 163475000 167325000        6 10.853541  1.884955e-25   -0.284
37 GroupB_1  chr5 167575000 180777630      134        NA            NA   -0.038
38 GroupB_1  chr6    155000 170952534      988        NA            NA    0.024
39 GroupB_1  chr7     55000 159039332      952        NA            NA    0.064
40 GroupB_1  chr8    105000 146277011      726        NA            NA   -0.133
41 GroupB_1  chr9    130000   8300000       20 10.897739  7.644010e-26    0.204
42 GroupB_1  chr9  10800000  68326090       60 16.752606  3.851767e-61    0.044
43 GroupB_1  chr9  71067734  79450000       17 10.918159  2.924101e-26   -0.235
44 GroupB_1  chr9  79625000  90250000       19 14.633854  7.577804e-47    0.014
45 GroupB_1  chr9  90475000  97450000       30 12.522876  2.179260e-34    0.225
46 GroupB_1  chr9  97650000  99925000       14  6.558129  2.436444e-09    0.074
47 GroupB_1  chr9 100150000 123625000       60 15.832035  3.243051e-54    0.217
48 GroupB_1  chr9 123675000 141076716      163        NA            NA    0.083
   seg.median
1      -0.114
2      -0.051
3       0.048
4      -0.081
5       0.061
6       0.203
7       0.014
8      -0.198
9      -0.049
10      0.099
11      0.351
12      0.141
13     -0.182
14     -0.177
15      0.113
16     -0.011
17     -0.145
18     -0.354
19     -0.033
20     -0.038
21     -0.365
22      0.059
23     -0.018
24      0.146
25      0.300
26     -0.079
27     -0.219
28     -0.028
29     -0.117
30      0.065
31      0.215
32      0.042
33     -0.116
34     -0.249
35     -0.040
36     -0.291
37     -0.029
38      0.031
39      0.067
40     -0.124
41      0.183
42      0.051
43     -0.232
44      0.014
45      0.230
46      0.071
47      0.227
48      0.079
> CNV.write(x, what = 'detail')
     chr     start       end     name   sample probes.Var1 probes.Freq  value
1   chr1 150547028 150554214     MCL1 GroupB_1        MCL1          18 -0.061
2   chr2  16078684  16087129     MYCN GroupB_1        MYCN          25  0.077
3   chr2 121552868 121750229     GLI2 GroupB_1        GLI2          86 -0.020
4   chr7  55084726  55275031     EGFR GroupB_1        EGFR          57  0.046
5   chr7  92234236  92465231     CDK6 GroupB_1        CDK6          54  0.108
6   chr7 116310460 116438440      MET GroupB_1         MET          24 -0.024
7   chr8  38268657  38328352    FGFR1 GroupB_1       FGFR1          36 -0.061
8   chr8 128746316 128753680      MYC GroupB_1         MYC          39 -0.027
9   chr9  21967752  22011312 CDKN2A/B GroupB_1    CDKN2A/B          14  0.064
10  chr9  98205265  98272831    PTCH1 GroupB_1       PTCH1          24  0.127
11 chr10  89621196  89728532     PTEN GroupB_1        PTEN          65 -0.025
12 chr11  69453874  69469242    CCND1 GroupB_1       CCND1          70  0.093
13 chr12  25358181  25405854     KRAS GroupB_1        KRAS          33  0.047
14 chr12  58141511  58148230     CDK4 GroupB_1        CDK4          24 -0.047
15 chr12  69199953  69239324     MDM2 GroupB_1        MDM2          15 -0.118
16 chr13  48875884  49056026      RB1 GroupB_1         RB1          61  0.294
17 chr17   7571721   7592868     TP53 GroupB_1        TP53          39 -0.140
18 chr17  29419946  29704695      NF1 GroupB_1         NF1          42 -0.216
19 chr17  37854255  37884915    ERBB2 GroupB_1       ERBB2          26 -0.106
20 chr19  30300902  30315215    CCNE1 GroupB_1       CCNE1          16  0.041
> CNV.write(x, what = 'bins')
      Chromosome     Start       End    Feature GroupB_1
1           chr1    521369    750000  chr1-0001   -0.103
2           chr1    750001    800000  chr1-0002   -0.125
3           chr1    800001    850000  chr1-0003   -0.149
4           chr1    850001    900000  chr1-0004   -0.079
5           chr1    900001    950000  chr1-0005   -0.069
6           chr1    950001   1000000  chr1-0006   -0.069
7           chr1   1000001   1050000  chr1-0007   -0.095
8           chr1   1050001   1100000  chr1-0008   -0.088
9           chr1   1100001   1150000  chr1-0009   -0.096
10          chr1   1150001   1200000  chr1-0010   -0.060
11          chr1   1200001   1250000  chr1-0011   -0.085
12          chr1   1250001   1300000  chr1-0012   -0.075
13          chr1   1300001   1350000  chr1-0013   -0.071
14          chr1   1350001   1400000  chr1-0014   -0.116
15          chr1   1400001   1450000  chr1-0015   -0.078
16          chr1   1450001   1500000  chr1-0016   -0.069
17          chr1   1500001   1550000  chr1-0017   -0.103
18          chr1   1550001   1600000  chr1-0018   -0.056
19          chr1   1600001   1650000  chr1-0019   -0.154
20          chr1   1650001   1700000  chr1-0020   -0.105
21          chr1   1700001   1800000  chr1-0021   -0.129
22          chr1   1800001   1850000  chr1-0022   -0.095
23          chr1   1850001   1900000  chr1-0023   -0.114
24          chr1   1900001   1950000  chr1-0024   -0.107
25          chr1   1950001   2000000  chr1-0025   -0.060
26          chr1   2000001   2050000  chr1-0026   -0.077
27          chr1   2050001   2100000  chr1-0027   -0.113
28          chr1   2100001   2150000  chr1-0028   -0.084
29          chr1   2150001   2200000  chr1-0029   -0.106
30          chr1   2200001   2250000  chr1-0030   -0.095
31          chr1   2250001   2300000  chr1-0031   -0.065
32          chr1   2300001   2350000  chr1-0032   -0.080
33          chr1   2350001   2400000  chr1-0033   -0.040
34          chr1   2400001   2450000  chr1-0034   -0.049
35          chr1   2450001   2500000  chr1-0035   -0.084
36          chr1   2500001   2550000  chr1-0036   -0.116
37          chr1   2550001   2634220  chr1-0037   -0.066
38          chr1   2684221   2750000  chr1-0038   -0.116
39          chr1   2750001   2800000  chr1-0039   -0.093
40          chr1   2800001   2850000  chr1-0040   -0.120
41          chr1   2850001   2900000  chr1-0041   -0.117
42          chr1   2900001   2950000  chr1-0042   -0.078
43          chr1   2950001   3000000  chr1-0043   -0.097
44          chr1   3000001   3050000  chr1-0044   -0.101
45          chr1   3050001   3100000  chr1-0045   -0.077
46          chr1   3100001   3150000  chr1-0046   -0.131
47          chr1   3150001   3200000  chr1-0047   -0.088
48          chr1   3200001   3250000  chr1-0048   -0.123
49          chr1   3250001   3300000  chr1-0049   -0.079
50          chr1   3300001   3350000  chr1-0050   -0.114
51          chr1   3350001   3400000  chr1-0051   -0.093
52          chr1   3400001   3450000  chr1-0052   -0.053
53          chr1   3450001   3500000  chr1-0053   -0.083
54          chr1   3500001   3550000  chr1-0054   -0.095
55          chr1   3550001   3600000  chr1-0055   -0.073
56          chr1   3600001   3650000  chr1-0056   -0.061
57          chr1   3650001   3700000  chr1-0057   -0.060
58          chr1   3700001   3750000  chr1-0058   -0.134
59          chr1   3750001   3800000  chr1-0059   -0.105
60          chr1   3800001   3845268  chr1-0060   -0.116
61          chr1   3995269   4150000  chr1-0061   -0.100
62          chr1   4150001   4200000  chr1-0062   -0.102
63          chr1   4200001   4450000  chr1-0063   -0.220
64          chr1   4450001   4500000  chr1-0064   -0.349
65          chr1   4500001   4700000  chr1-0065   -0.104
66          chr1   4700001   4750000  chr1-0066   -0.139
67          chr1   4750001   4800000  chr1-0067   -0.115
68          chr1   4800001   4850000  chr1-0068   -0.206
69          chr1   4850001   5550000  chr1-0069   -0.232
70          chr1   5550001   5750000  chr1-0070   -0.142
71          chr1   5750001   5800000  chr1-0071   -0.122
72          chr1   5800001   5900000  chr1-0072   -0.225
73          chr1   5900001   5950000  chr1-0073   -0.096
74          chr1   5950001   6050000  chr1-0074   -0.121
75          chr1   6050001   6100000  chr1-0075   -0.121
76          chr1   6100001   6150000  chr1-0076   -0.096
77          chr1   6150001   6200000  chr1-0077   -0.060
78          chr1   6200001   6250000  chr1-0078   -0.152
79          chr1   6250001   6300000  chr1-0079   -0.120
80          chr1   6300001   6350000  chr1-0080   -0.070
81          chr1   6350001   6400000  chr1-0081   -0.130
82          chr1   6400001   6450000  chr1-0082   -0.170
83          chr1   6450001   6500000  chr1-0083   -0.090
84          chr1   6500001   6550000  chr1-0084   -0.100
85          chr1   6550001   6600000  chr1-0085   -0.116
86          chr1   6600001   6650000  chr1-0086   -0.057
87          chr1   6650001   6700000  chr1-0087   -0.073
88          chr1   6700001   6800000  chr1-0088   -0.206
89          chr1   6800001   6850000  chr1-0089   -0.257
90          chr1   6850001   7000000  chr1-0090   -0.235
91          chr1   7000001   7100000  chr1-0091   -0.158
92          chr1   7100001   7150000  chr1-0092   -0.181
93          chr1   7150001   7300000  chr1-0093   -0.245
94          chr1   7300001   7450000  chr1-0094   -0.187
95          chr1   7450001   7550000  chr1-0095   -0.099
96          chr1   7550001   7700000  chr1-0096   -0.130
97          chr1   7700001   7750000  chr1-0097   -0.095
98          chr1   7750001   7800000  chr1-0098   -0.132
99          chr1   7800001   7850000  chr1-0099   -0.165
100         chr1   7850001   8000000  chr1-0100   -0.242
101         chr1   8000001   8050000  chr1-0101   -0.158
102         chr1   8050001   8100000  chr1-0102   -0.212
103         chr1   8100001   8250000  chr1-0103   -0.336
104         chr1   8250001   8350000  chr1-0104   -0.149
105         chr1   8350001   8400000  chr1-0105   -0.120
106         chr1   8400001   8450000  chr1-0106   -0.107
107         chr1   8450001   8500000  chr1-0107   -0.224
108         chr1   8500001   8700000  chr1-0108   -0.163
109         chr1   8700001   8850000  chr1-0109   -0.233
110         chr1   8850001   8900000  chr1-0110   -0.129
111         chr1   8900001   8950000  chr1-0111   -0.136
112         chr1   8950001   9050000  chr1-0112   -0.196
113         chr1   9050001   9100000  chr1-0113   -0.175
114         chr1   9100001   9150000  chr1-0114   -0.147
115         chr1   9150001   9200000  chr1-0115   -0.221
116         chr1   9200001   9250000  chr1-0116   -0.116
117         chr1   9250001   9300000  chr1-0117   -0.133
118         chr1   9300001   9350000  chr1-0118   -0.087
119         chr1   9350001   9400000  chr1-0119   -0.149
120         chr1   9400001   9450000  chr1-0120   -0.112
121         chr1   9450001   9550000  chr1-0121   -0.224
122         chr1   9550001   9600000  chr1-0122   -0.120
123         chr1   9600001   9650000  chr1-0123   -0.221
124         chr1   9650001   9700000  chr1-0124   -0.110
125         chr1   9700001   9750000  chr1-0125   -0.193
126         chr1   9750001   9800000  chr1-0126   -0.115
127         chr1   9800001   9900000  chr1-0127   -0.157
128         chr1   9900001  10000000  chr1-0128   -0.092
129         chr1  10000001  10050000  chr1-0129   -0.079
130         chr1  10050001  10100000  chr1-0130   -0.179
131         chr1  10100001  10350000  chr1-0131   -0.131
132         chr1  10350001  10450000  chr1-0132   -0.161
133         chr1  10450001  10500000  chr1-0133   -0.125
134         chr1  10500001  10550000  chr1-0134   -0.143
135         chr1  10550001  10650000  chr1-0135   -0.228
136         chr1  10650001  10700000  chr1-0136   -0.119
137         chr1  10700001  10750000  chr1-0137   -0.089
138         chr1  10750001  10800000  chr1-0138   -0.120
139         chr1  10800001  10850000  chr1-0139   -0.138
140         chr1  10850001  10900000  chr1-0140   -0.133
141         chr1  10900001  11000000  chr1-0141   -0.154
142         chr1  11000001  11100000  chr1-0142   -0.117
143         chr1  11100001  11150000  chr1-0143   -0.075
144         chr1  11150001  11300000  chr1-0144   -0.186
145         chr1  11300001  11350000  chr1-0145   -0.132
146         chr1  11350001  11500000  chr1-0146   -0.179
147         chr1  11500001  11550000  chr1-0147   -0.099
148         chr1  11550001  11700000  chr1-0148   -0.096
149         chr1  11700001  11750000  chr1-0149   -0.114
150         chr1  11750001  11800000  chr1-0150   -0.151
151         chr1  11800001  11850000  chr1-0151   -0.042
152         chr1  11850001  11900000  chr1-0152   -0.113
153         chr1  11900001  11950000  chr1-0153   -0.070
154         chr1  11950001  12000000  chr1-0154   -0.096
155         chr1  12000001  12050000  chr1-0155   -0.106
156         chr1  12050001  12100000  chr1-0156   -0.124
157         chr1  12100001  12150000  chr1-0157   -0.271
158         chr1  12150001  12200000  chr1-0158   -0.171
159         chr1  12200001  12250000  chr1-0159   -0.173
160         chr1  12250001  12300000  chr1-0160   -0.106
161         chr1  12300001  12500000  chr1-0161   -0.295
162         chr1  12500001  12550000  chr1-0162   -0.277
163         chr1  12550001  12600000  chr1-0163   -0.089
164         chr1  12600001  12650000  chr1-0164   -0.162
165         chr1  12650001  12700000  chr1-0165   -0.153
166         chr1  12700001  12800000  chr1-0166   -0.229
167         chr1  12800001  12900000  chr1-0167   -0.160
168         chr1  12900001  13052998  chr1-0168   -0.240
169         chr1  13607163  13900000  chr1-0169   -0.140
170         chr1  13900001  14000000  chr1-0170   -0.127
171         chr1  14000001  14050000  chr1-0171   -0.264
172         chr1  14050001  14100000  chr1-0172   -0.167
173         chr1  14100001  14150000  chr1-0173   -0.262
174         chr1  14150001  14550000  chr1-0174   -0.275
175         chr1  14550001  14900000  chr1-0175   -0.232
176         chr1  14900001  14950000  chr1-0176   -0.012
177         chr1  14950001  15150000  chr1-0177   -0.229
178         chr1  15150001  15250000  chr1-0178   -0.232
179         chr1  15250001  15300000  chr1-0179   -0.202
180         chr1  15300001  15450000  chr1-0180   -0.136
181         chr1  15450001  15500000  chr1-0181   -0.203
182         chr1  15500001  15550000  chr1-0182   -0.086
183         chr1  15550001  15700000  chr1-0183   -0.125
184         chr1  15700001  15750000  chr1-0184   -0.213
185         chr1  15750001  15850000  chr1-0185   -0.149
186         chr1  15850001  15900000  chr1-0186   -0.216
187         chr1  15900001  15950000  chr1-0187   -0.123
188         chr1  15950001  16050000  chr1-0188   -0.195
189         chr1  16050001  16100000  chr1-0189   -0.073
190         chr1  16100001  16250000  chr1-0190   -0.141
191         chr1  16250001  16300000  chr1-0191   -0.082
192         chr1  16300001  16350000  chr1-0192   -0.134
193         chr1  16350001  16400000  chr1-0193   -0.072
194         chr1  16400001  16450000  chr1-0194   -0.106
195         chr1  16450001  16500000  chr1-0195   -0.133
196         chr1  16500001  16550000  chr1-0196   -0.060
197         chr1  16550001  16600000  chr1-0197   -0.116
198         chr1  16600001  16700000  chr1-0198   -0.150
199         chr1  16700001  16800000  chr1-0199   -0.145
200         chr1  16800001  16850000  chr1-0200   -0.095
201         chr1  16850001  16900000  chr1-0201   -0.107
202         chr1  16900001  16950000  chr1-0202   -0.131
203         chr1  16950001  17000000  chr1-0203   -0.139
204         chr1  17000001  17050000  chr1-0204   -0.023
205         chr1  17050001  17125658  chr1-0205   -0.066
206         chr1  17175659  17200000  chr1-0206   -0.030
207         chr1  17200001  17250000  chr1-0207   -0.048
208         chr1  17250001  17300000  chr1-0208   -0.078
209         chr1  17300001  17350000  chr1-0209   -0.081
210         chr1  17350001  17400000  chr1-0210   -0.059
211         chr1  17400001  17500000  chr1-0211   -0.144
212         chr1  17500001  17550000  chr1-0212   -0.142
213         chr1  17550001  17600000  chr1-0213   -0.201
214         chr1  17600001  17700000  chr1-0214   -0.159
215         chr1  17700001  17750000  chr1-0215   -0.146
216         chr1  17750001  17800000  chr1-0216   -0.105
217         chr1  17800001  17900000  chr1-0217   -0.115
218         chr1  17900001  17950000  chr1-0218   -0.071
219         chr1  17950001  18050000  chr1-0219   -0.101
220         chr1  18050001  18400000  chr1-0220   -0.175
221         chr1  18400001  18450000  chr1-0221   -0.123
222         chr1  18450001  18650000  chr1-0222   -0.131
223         chr1  18650001  18800000  chr1-0223   -0.182
224         chr1  18800001  18950000  chr1-0224   -0.148
225         chr1  18950001  19000000  chr1-0225   -0.064
226         chr1  19000001  19050000  chr1-0226   -0.206
227         chr1  19050001  19150000  chr1-0227   -0.116
228         chr1  19150001  19200000  chr1-0228   -0.151
229         chr1  19200001  19250000  chr1-0229   -0.079
230         chr1  19250001  19300000  chr1-0230   -0.099
231         chr1  19300001  19500000  chr1-0231   -0.117
232         chr1  19500001  19550000  chr1-0232   -0.192
233         chr1  19550001  19600000  chr1-0233   -0.147
234         chr1  19600001  19650000  chr1-0234   -0.168
235         chr1  19650001  19700000  chr1-0235   -0.102
236         chr1  19700001  19800000  chr1-0236   -0.224
237         chr1  19800001  19900000  chr1-0237   -0.118
238         chr1  19900001  19950000  chr1-0238   -0.142
239         chr1  19950001  20000000  chr1-0239   -0.085
240         chr1  20000001  20100000  chr1-0240   -0.148
241         chr1  20100001  20150000  chr1-0241   -0.156
242         chr1  20150001  20250000  chr1-0242   -0.119
243         chr1  20250001  20350000  chr1-0243   -0.168
244         chr1  20350001  20450000  chr1-0244   -0.185
245         chr1  20450001  20500000  chr1-0245   -0.113
246         chr1  20500001  20550000  chr1-0246   -0.174
247         chr1  20550001  20650000  chr1-0247   -0.155
248         chr1  20650001  20700000  chr1-0248   -0.112
249         chr1  20700001  20800000  chr1-0249   -0.133
250         chr1  20800001  20850000  chr1-0250   -0.121
251         chr1  20850001  20950000  chr1-0251   -0.030
252         chr1  20950001  21000000  chr1-0252   -0.135
253         chr1  21000001  21050000  chr1-0253   -0.075
254         chr1  21050001  21100000  chr1-0254   -0.106
255         chr1  21100001  21500000  chr1-0255   -0.151
256         chr1  21500001  21600000  chr1-0256   -0.157
257         chr1  21600001  21650000  chr1-0257   -0.116
258         chr1  21650001  21750000  chr1-0258   -0.129
259         chr1  21750001  21800000  chr1-0259   -0.040
260         chr1  21800001  21850000  chr1-0260   -0.065
261         chr1  21850001  21900000  chr1-0261   -0.228
262         chr1  21900001  21950000  chr1-0262   -0.103
263         chr1  21950001  22100000  chr1-0263   -0.164
264         chr1  22100001  22150000  chr1-0264   -0.068
265         chr1  22150001  22200000  chr1-0265   -0.091
266         chr1  22200001  22250000  chr1-0266   -0.095
267         chr1  22250001  22350000  chr1-0267   -0.167
268         chr1  22350001  22400000  chr1-0268   -0.178
269         chr1  22400001  22450000  chr1-0269   -0.139
270         chr1  22450001  22500000  chr1-0270   -0.120
271         chr1  22500001  22650000  chr1-0271   -0.110
272         chr1  22650001  22800000  chr1-0272   -0.138
273         chr1  22800001  22900000  chr1-0273   -0.057
274         chr1  22900001  22950000  chr1-0274   -0.097
275         chr1  22950001  23000000  chr1-0275   -0.074
276         chr1  23000001  23050000  chr1-0276   -0.145
277         chr1  23050001  23150000  chr1-0277   -0.106
278         chr1  23150001  23300000  chr1-0278   -0.087
279         chr1  23300001  23450000  chr1-0279   -0.124
280         chr1  23450001  23500000  chr1-0280   -0.268
281         chr1  23500001  23650000  chr1-0281   -0.138
282         chr1  23650001  23700000  chr1-0282   -0.156
283         chr1  23700001  23800000  chr1-0283   -0.139
284         chr1  23800001  23850000  chr1-0284   -0.116
285         chr1  23850001  23900000  chr1-0285   -0.134
286         chr1  23900001  24050000  chr1-0286   -0.254
287         chr1  24050001  24100000  chr1-0287   -0.034
288         chr1  24100001  24150000  chr1-0288   -0.147
289         chr1  24150001  24200000  chr1-0289   -0.152
290         chr1  24200001  24250000  chr1-0290   -0.170
291         chr1  24250001  24350000  chr1-0291   -0.148
292         chr1  24350001  24500000  chr1-0292   -0.137
293         chr1  24500001  24600000  chr1-0293   -0.131
294         chr1  24600001  24700000  chr1-0294   -0.180
295         chr1  24700001  24750000  chr1-0295   -0.144
296         chr1  24750001  24850000  chr1-0296   -0.086
297         chr1  24850001  24950000  chr1-0297   -0.266
298         chr1  24950001  25050000  chr1-0298   -0.122
299         chr1  25050001  25100000  chr1-0299   -0.106
300         chr1  25100001  25200000  chr1-0300   -0.147
301         chr1  25200001  25250000  chr1-0301   -0.158
302         chr1  25250001  25300000  chr1-0302   -0.111
303         chr1  25300001  25550000  chr1-0303   -0.123
304         chr1  25550001  25600000  chr1-0304   -0.125
305         chr1  25600001  25750000  chr1-0305   -0.171
306         chr1  25750001  25850000  chr1-0306   -0.234
307         chr1  25850001  25900000  chr1-0307   -0.080
308         chr1  25900001  25950000  chr1-0308   -0.097
309         chr1  25950001  26100000  chr1-0309   -0.186
310         chr1  26100001  26150000  chr1-0310   -0.156
311         chr1  26150001  26200000  chr1-0311   -0.124
312         chr1  26200001  26250000  chr1-0312   -0.118
313         chr1  26250001  26350000  chr1-0313   -0.151
314         chr1  26350001  26400000  chr1-0314   -0.114
315         chr1  26400001  26450000  chr1-0315   -0.093
316         chr1  26450001  26500000  chr1-0316   -0.063
317         chr1  26500001  26550000  chr1-0317   -0.128
318         chr1  26550001  26600000  chr1-0318   -0.143
319         chr1  26600001  26650000  chr1-0319   -0.099
320         chr1  26650001  26700000  chr1-0320   -0.161
321         chr1  26700001  26750000  chr1-0321   -0.102
322         chr1  26750001  26800000  chr1-0322   -0.105
323         chr1  26800001  26900000  chr1-0323   -0.169
324         chr1  26900001  27100000  chr1-0324   -0.142
325         chr1  27100001  27150000  chr1-0325   -0.188
326         chr1  27150001  27200000  chr1-0326   -0.092
327         chr1  27200001  27250000  chr1-0327   -0.168
328         chr1  27250001  27300000  chr1-0328   -0.095
329         chr1  27300001  27350000  chr1-0329   -0.136
330         chr1  27350001  27450000  chr1-0330   -0.077
331         chr1  27450001  27500000  chr1-0331   -0.149
332         chr1  27500001  27600000  chr1-0332   -0.131
333         chr1  27600001  27650000  chr1-0333   -0.106
334         chr1  27650001  27700000  chr1-0334   -0.090
335         chr1  27700001  27750000  chr1-0335   -0.119
336         chr1  27750001  27850000  chr1-0336   -0.139
337         chr1  27850001  27900000  chr1-0337   -0.093
338         chr1  27900001  27950000  chr1-0338   -0.133
339         chr1  27950001  28000000  chr1-0339   -0.165
340         chr1  28000001  28150000  chr1-0340   -0.128
341         chr1  28150001  28200000  chr1-0341   -0.119
342         chr1  28200001  28250000  chr1-0342   -0.121
343         chr1  28250001  28400000  chr1-0343   -0.110
344         chr1  28400001  28450000  chr1-0344   -0.182
345         chr1  28450001  28550000  chr1-0345   -0.207
346         chr1  28550001  28600000  chr1-0346   -0.183
347         chr1  28600001  28800000  chr1-0347   -0.133
348         chr1  28800001  28850000  chr1-0348   -0.201
349         chr1  28850001  28900000  chr1-0349   -0.126
350         chr1  28900001  28950000  chr1-0350   -0.104
351         chr1  28950001  29000000  chr1-0351   -0.149
352