Last data update: 2014.03.03
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R: Direct p-value combination
directpvalcombi | R Documentation |
Direct p-value combination
Description
Combines one sided p-values with the inverse normal method.
Usage
directpvalcombi(pvalonesided, nrep, BHth = 0.05)
Arguments
pvalonesided |
List of vectors of one sided p-values to be combined.
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nrep |
Vector of numbers of replicates used in each study to calculate the previous one-sided p-values.
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BHth |
Benjamini Hochberg threshold. By default, the False Discovery Rate is controlled at 5%.
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Value
List
DEindices |
Indices of differentially expressed genes at the chosen Benjamini Hochberg threshold.
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TestStatistic |
Vector with test statistics for differential expression in the meta-analysis.
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Note
One-sided p-values are required to avoid directional conflicts. Then a two-sided test is performed
to find differentially expressed genes.
Author(s)
Guillemette Marot
References
Hedges, L. and Olkin, I. (1985). Statistical Methods for Meta-Analysis. Academic
Press.
Results
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