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Last data update: 2014.03.03

R: Strimmer et al.'s fdrtool-based local fdr

pval2locfdr

R Documentation

Strimmer et al.'s fdrtool-based local fdr

Description

The function pval2locfdr takes a vector of p-values and estimates for each case the local fdr.

Usage

pval2locfdr(pValues, cutoff)

Arguments

`pValues`	pValues to be used.
`cutoff`	The local fdr cutoff for rejection. Hypotheses with `local fdr` smaller then `cutoff` will be rejected.

Value

A list containing:

`locfdr`	Numeric vector with local FDR values for each case
`rejected`	Logical vector indicating rejection/retention for each hypothesis when a `cutoff` is supplied.

Author(s)

JonathanRosenblatt

References

Strimmer, K. (2008). fdrtool: a versatile R package for estimating local and tail area-based false discovery rates. Bioinformatics 24: 1461-1462.
Efron B., Tibshirani R., Storey J. D. and Tusher, V. (2001). Empirical Bayes Analysis of a Microarray Experiment. Journal of the American Statistical Association 96(456):1151-1160.

Examples

pvals<- runif(1000)^2
pval2locfdr(pvals)
pval2locfdr(pValues=pvals, cutoff=0.4)