Represents any randomization procedure for a two-armed clinical trial.
Usage
createParam(method, N, mti, bc, rb, p, ini, add, filledBlock)
Arguments
method
method that is used to generate the (random) allocation
sequence. It can take values PBR, RAR, HAD, PWR,
EBC, BSD, CR, TBD, UD, and MP.
N
integer for the total sample size of the trial.
mti
maximum tolerated imbalance in patient numbers during the trial.
bc
vector which contains the lengths k_1,...,k_l of each block.
This means that the vector bc will have one entry for each block.
rb
block lengths of the blocks that can be selected equiprobable at random.
p
success probability of the biased coin (e.g. in Efron's Biased Coin
Design).
ini
integer representing the initial urn composition.
add
integer representing the number of balls that are added to the
urn in each step.
filledBlock
logical whether the last block should be filled or not.
Details
Dending on the input of the user, createParam creates an object
representing a randomization procedures for a two-armed clinical trial
(see also randPar).
Value
S4object of the corresponding randomization procedure class.