Represents the randomization procedure Permuted Block Randomization.
Usage
pbrPar(bc, K = 2, ratio = rep(1, K), groups = LETTERS[1:K])
Arguments
bc
vector which contains the lengths k_1,...,k_l of each block.
This means that the vector bc will have one entry for each block.
K
number of treatment groups (e.g. K=2 if we compare one experimental
against one control treatment).
ratio
vector of length K. The total sample number N and
all used block lengths (bc) have to be divisible by sum(ratio).
groups
character vector of labels for the different treatments.
Details
Fix the block constellation bc, the number of treatment groups K,
and the vector of the ratio. Afterwards,
in each block the patients are assigned according to the ratio to the
corresponding treatment groups. All generated randomization sequences
are equiprobable.
Value
S4 object of the class pbrPar.
References
W. F. Rosenberger and J. M. Lachin (2002) Randomization in Clinical Trials.
Wiley.