This class is used to compare designs and methodologies frequentist and bayesian properties. To use it create a list of trial designs of class trialDesign_binom_two and assign the class as list_trialDesign_binom_two (class(x)=c("list_trialDesign_binom_two",class(x))).
Bayesian sample size calculation software and examples for Eurosarc clinical trials which utilise Bayesian methodology for binary endpoints (response/no-response). These trials rely on binomial based endpoints so the majority of programs found here relate to this sort of endpoint. Interim analyses are permitted for most designs. Developed as part of the EuroSARC FP7 grant.
Sample size calculation for single arm, two stage designs (Simon's optimal and minmax designs) where stoping early for futility is permitted. Returns frequentist and Bayesian properties for the designs.
This function searches for solutions to a single arm two-stage two-endpoint trial first proposed by Bryant and Day (1995). The two endpoints are assumed independent. A wrapper function to compute the Bayesian properties is also provided.