This function allow to the user to create a ExpressionSet object from a matrix representing an omics dataset. It allows to include the experimental design and annotation in the ExpressionSet object.
holistOmics
(Package: STATegRa) :
HolistOmics an application of NPC on omics datasets
This function applies the NonParametric Combination methodology on the integrative analysis of different omics data modalities. It retrieves diffential expressed genes between control and treatment, taking into account all omics data. First, each datatype is analyzed independently using the appropriate method. HolistOmics analyses static (one time point) RNAseq, using Voom+limma method, and static (one time point) Microarray, using limma. Then, the resulting p-values are combined employing Fisher, Liptak and Tippett combining functions. Tippett function returns findings which are supported by at least one omics modality. Liptak function returns findings which are supportd by most modalities. Fisher function has an intermediate behavior between those of Tippett and Liptak.