All analysis steps are integrate into a pipeline. The results, including visualization plots are placed in a directory as specified by user.
● Data Source:
CranContrib
● Keywords: CNV, NGS, pipeline
● Alias: NGS.CNV
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0 images
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This function adjusts log2ratio by GC content using LOESS.
● Data Source:
CranContrib
● Keywords: CNV, GC content
● Alias: GC.adjust
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0 images
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It is an option to merge adjacent segments, for which the median values in either or both log2ratio and log2mBAF dimensions are not substantially different. For WGS and SNP array, it is recommended to do so.
● Data Source:
CranContrib
● Keywords: merge, segmentation
● Alias: merging.segments
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0 images
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We employ the algorithm developed by (Zhang et al., 2010) to perform joint segmentation on log2ratio and log2mBAF dimensions. The function outputs the starting and ending points of each CNV segment as well as some summary statistics.
● Data Source:
CranContrib
● Keywords: CBS, joint segmentation, segmentation
● Alias: joint.segmentation
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Refine the segment boundaries based on the grid of heterozygous probes by all probes with LRR data. We do not recommend to perform this step except in the case that the segment boundaries need to be aligned well on the same grid of probes for downstream analysis.
● Data Source:
CranContrib
● Keywords: CNV, SNP array
● Alias: snp.refine.boundary
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Transform read depth information into log2ratio and log2mBAF that we use for joint segmentation and CNV calling.
● Data Source:
CranContrib
● Keywords: CNV
● Alias: cnv.data
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It parses a VCF file and extract necessary information for CNV analysis.
● Data Source:
CranContrib
● Keywords: vcf
● Alias: vcf2txt
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Assign SCNA state to each segment directly from joint segmentation or from the results after segments merging step.
● Data Source:
CranContrib
● Keywords: CNV, CNV call
● Alias: cnv.call
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0 images
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All analysis steps are integrate into a pipeline. The results, including visualization plots are placed in a directory as specified by user.
● Data Source:
CranContrib
● Keywords: CNV, SNP array, pipeline
● Alias: SNP.CNV
●
0 images
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Perform joint segmentation on two signal dimensions derived from total read depth (intensity) and allele specific read depth (intensity) for whole genome sequencing (WGS), whole exome sequencing (WES) and SNP array data.
● Data Source:
CranContrib
● Keywords:
● Alias: saasCNV, saasCNV-package
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