R: Alignment of basic Helix Loop Helix (bHLH) domain data
bHLH288
R Documentation
Alignment of basic Helix Loop Helix (bHLH) domain data
Description
The bHLH domain has been categorized into 5 major classes (Atchley and Fitch 1997).
The bHLH288 dataset contains 288 amino acid sequences with samples from each class. While the
basic and helix regions have well defined structures consisting of 13 and 15 amino acids respectively,
the loop region has variable length. To prevent gaps, the loop was truncated in some proteins so only 51
sites are retained and partitioned into basic (1-13), helix(14-28), loop (29-36), and helix(37-51) regions.
Details
The bHLH domain is present throughout Eukaryotes and acts as a transcriptional regulator.
This alignment consists of 51 sites where the first 13 constitute the basic region responsible
for DNA binding. Each of the 2 helices are 15 amino acids in length, while the loop is variable.
Groups are specified by several factors, including the E-box binding specification and inclusion
or lack of other domains. The 5 groups are designated by their E-box specificity and presence of
additional domains where Group A binds to CAGCTG E-box motif, Group B binds to CACGTG E-box motif
and is most prevalent, Group C has an additional PAS domain, Group D lacks a basic region, and
Group E binds to CACG[C/A]G N-box motif.
Source
Atchley, W.R. and Fitch, W. (1997) A natural classification of the basic helix-loop-helix class of
transcription factors. Proc. Natl. Acad. Sci. USA 94: 5172-5176.
Atchley, W.R. and Fernandes, A. (2005) Sequence signatures and the probabilistic identification of
proteins in the Myc-Max-Mad network. Proc. Natl. Acad. Sci. USE 102: 6401-6406
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> library(HDMD)
Loading required package: psych
Loading required package: MASS
> png(filename="/home/ddbj/snapshot/RGM3/R_CC/result/HDMD/bHLH288.Rd_%03d_medium.png", width=480, height=480)
> ### Name: bHLH288
> ### Title: Alignment of basic Helix Loop Helix (bHLH) domain data
> ### Aliases: bHLH288
> ### Keywords: datasets
>
> ### ** Examples
>
> data(bHLH288)
Warning message:
In data(bHLH288) : data set 'bHLH288' not found
>
> #Separate grouping and sequences
> grouping = t(bHLH288[,1])
> bHLH_Seq = as.vector(bHLH288[,2])
>
>
>
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>
> dev.off()
null device
1
>