The Cefamandole data frame has 84 rows and 3 columns.
Format
This data frame contains the following columns:
Subject
a factor giving the subject from which the sample was drawn.
Time
a numeric vector giving the time at which the sample was drawn
(minutes post-injection).
conc
a numeric vector giving the observed plasma concentration of
cefamandole (mcg/ml).
Details
Davidian and Giltinan (1995, 1.1, p. 2) describe data
obtained during a pilot study to investigate the pharmacokinetics of
the drug cefamandole. Plasma concentrations of the drug were measured
on six healthy volunteers at 14 time points following an intraveneous
dose of 15 mg/kg body weight of cefamandole.
Source
Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S
and S-PLUS, Springer, New York. (Appendix A.4)
Davidian, M. and Giltinan, D. M. (1995), Nonlinear Models for
Repeated Measurement Data, Chapman and Hall, London.
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> library(MEMSS)
Loading required package: lme4
Loading required package: Matrix
Attaching package: 'MEMSS'
The following objects are masked from 'package:datasets':
CO2, Orange, Theoph
> png(filename="/home/ddbj/snapshot/RGM3/R_CC/result/MEMSS/Cefamandole.Rd_%03d_medium.png", width=480, height=480)
> ### Name: Cefamandole
> ### Title: Pharmacokinetics of Cefamandole
> ### Aliases: Cefamandole
> ### Keywords: datasets
>
> ### ** Examples
>
> require(lattice)
Loading required package: lattice
> str(Cefamandole)
'data.frame': 84 obs. of 3 variables:
$ Subject: Factor w/ 6 levels "A","B","C","D",..: 1 1 1 1 1 1 1 1 1 1 ...
$ Time : num 10 15 20 30 45 60 75 90 120 150 ...
$ conc : num 127 80 47.4 39.9 24.8 17.9 11.7 10.9 5.7 2.55 ...
> xyplot(conc ~ Time, Cefamandole, groups = Subject, type = c("g", "b"),
+ aspect = 'xy', scales = list(y = list(log = 2)),
+ auto.key = list(space = "right", lines= TRUE))
> xyplot(conc ~ Time|Subject, Cefamandole, type = c("g", "b"),
+ index.cond = function(x,y) min(y), aspect = 'xy',
+ scales = list(y = list(log = 2)))
> #fm1 <- nlsList(SSbiexp, data = Cefamandole)
>
>
>
>
>
> dev.off()
null device
1
>