Levels of expressed alpha synuclein mRNA in three groups of allele lengths of
NACP-REP1.
Usage
alpha
Format
A data frame with 97 observations on 2 variables.
alength
allele length, a factor with levels "short", "intermediate"
and "long".
elevel
expression levels of alpha synuclein mRNA.
Details
Various studies have linked alcohol dependence phenotypes to chromosome 4.
One candidate gene is NACP (non-amyloid component of plaques), coding for
alpha synuclein. Bönsch et al. (2005) found longer
alleles of NACP-REP1 in alcohol-dependent patients compared with healthy
controls and reported that the allele lengths show some association with
levels of expressed alpha synuclein mRNA.
Source
Bönsch, D., Lederer, T., Reulbach, U., Hothorn, T., Kornhuber,
J. and Bleich, S. (2005). Joint analysis of the NACP-REP1 marker
within the alpha synuclein gene concludes association with alcohol dependence.
Human Molecular Genetics14(7), 967–971.
References
Hothorn, T., Hornik, K., van de Wiel, M. A. and Zeileis, A. (2006). A Lego
system for conditional inference. The American Statistician60(3), 257–263.
Examples
## Boxplots
boxplot(elevel ~ alength, data = alpha)
## Asymptotic Kruskal-Wallis test
kruskal_test(elevel ~ alength, data = alpha)