PREDIMED randomized trial

Description

The PREDIMED trial (Prevenci<c3><b3>n con Dieta Mediterr<c3><a1>nea) is a randomized, parallel and multicentric cohort with more than 7,000 participants who were randomly assigned to three diet groups (olive oil + mediterranean diet, nuts + mediterranean diet, and low-fat diet -control group-) and followed-up during more than 7 years.

Usage

data(predimed)

Format

A data frame with 6324 observations on the following 15 variables:

group

a factor with levels Control MedDiet + Nuts MedDiet + VOO. Intervention group.

sex

a factor with levels Male Female.Sex.

age

Age.

smoke

a factor with levels Never Current Former.Smoking.

bmi

Body mass index.

waist

Waist circumference.

wth

Waist-to-height ratio.

htn

a factor with levels No Yes.Hypertension.

diab

a factor with levels No Yes .Type-2 diabetes.

hyperchol

a factor with levels No Yes.Dyslipidemia.

famhist

a factor with levels No Yes.Family history of premature CHD.

hormo

a factor with levels No Yes.Hormone-replacement therapy.

p14

MeDiet Adherence score.

toevent

follow-up to main event (years).

event

a factor with levels No Yes.AMI, stroke, or CV Death.

Details

Participants of PREDIMED study were recruited in 2003 and were revisited anually until 2010. In each visit, a large variety of different information was collected: antropometric (body mass index, age, ...), blood samples (Total cholesterol, HDL cholesterol, ...), dietary pattern consumtion using validated questionaries, treatments, etc. Also, cardiovascular events were recorded during the follow-up period. At recruitment period, each participant was assigned to each of the three diet type group. Periodically (every 6-months approximately), participants were advised to follow the diet corresponding to their group. To build this example data set approx 85% of original participants were randomly selected. For more information about this data set, see the vignette.

Source

For more information about the study these data come from, visit http://predimed.onmedic.net/.

References

Estruch R, Ros E, Salas-Salvad<c3><b3> J, Covas MI, Corella D, Ar<c3><b3>s F, G<c3><b3>mez-Gracia E, Ruiz-Guti<c3><a9>rrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pint<c3><b3> X, Basora J, Mu<c3><b1>oz MA, Sorl<c3><ad> JV, Mart<c3><ad>nez JA, Mart<c3><ad>nez-Gonz<c3><a1>lez MA; PREDIMED Study Investigators (2013). Primary prevention of cardiovascular disease with a Mediterranean diet. New England Journal of Medicine 368(14): 1279-1290.

Examples

require(compareGroups)
data(predimed)
summary(predimed)

Results