Minnesota Breast Cancer Study

Description

Data from the Minnesota Breast Cancer Family Study. This contains extended pedigrees from 426 families, each identified by a single proband in 1945-52, with follow up for incident breast cancer.

Usage

data(minnbreast)

Format

minnbreast: A data frame with 29114 observations, one line per subject, on the following 14 variables. minnbreast2: Further data on oral contraceptive use and related risk factors in 6150 female subjects.

id

subject identifier

proband

if 1, this subject is one of the original 426 probands

fatherid

identifier of the father, if the father is part of the data set; zero otherwise

motherid

identifier of the mother, if the mother is part of the data set; zero otherwise

famid

family identifier

endage

age at last follow-up or incident cancer

cancer

1= breast cancer (females) or prostate cancer (males), 0=censored

yob

year of birth

education

amount of education: 1-8 years, 9-12 years, high school graduate, vocational education beyond high school, some college but did not graduate, college graduate, post-graduate education, refused to answer on the questionairre

marstat

marital status: married, living with someone in a marriage-like relationship, separated or divorced, widowed, never married, refused to answer the questionaiire

everpreg

ever pregnant: never pregnant at the time of baseline survey, ever pregnant at the time of baseline survey

parity

number of births

sex

M or F

bcpc

part of one of the families in the breast/prostate cancer substudy: 0=no, 1=yes. Note that subjects who were recruited to the overall study after the date of the BP substudy are coded as zero.

id

subject identifier

startage

starting age for follow-up

endage

age at last follow-up or incident breast cancer

cancer

1=incident breast cancer, 0=censored

oralc

current oral contraceptive use: none, <=4 years, > 4 years

degree

familial relationship to the proband: first degree, second degree, or marry-in

par.brth

a combination of parity and childbearing age: nullparous (no children), 2 children with the first by age 20, 1-2 children after age 20, 3+ children with the first by age 20, or 3+ children after age 20.

agemen

age at first menarche

meno

age of menopause: currently pre-menopausal, before age 45, age 45-50, after age 50

ooph

oophorectomy: 0=no, 1=yes

packyr

pack years of smoking: never smoker, 20 or less, more than 20

Details

The original study was conducted by Dr. Elving Anderson at the Dight Institute for Human Genetics at the University of Minnesota. From 1944 to 1952, 544 sequential breast cancer cases seen at the University Hospital were enrolled, and information gathered on parents, siblings, offspring, aunts/uncles, and grandparents with the goal of understanding possible familial aspects of brest cancer. In 1991 the study was resurrected by Dr. Tom Sellers. Of the original 544 he excluded 58 prevalent cases, along with another 19 who had less than 2 living relatives at the time of Dr Anderson's survey. Of the remaining 462 families 10 had no living members, 23 could not be located and 8 refused, leaving 426 families on whom updated pedigrees were obtained. This gave a study with 13351 males and 12699 females (5183 marry-ins). Primary questions were the relationship of early life exposures, breast density, and pharmacogenomics on incident breast cancer risk.

For a subset of the families data was gathered on prostate cancer risk for male subjects via questionairres sent to men over 40. Other than this, data items other than parentage are limited to the female subjects.

In ___ a second phase of the study was instituted. The pedigrees were further extended to the numbers found in this data set, and further data gathered by questionairre.

The second data set contains time dependent covariates and so is coded in a (start, stop) style. It is also more refined with respect to marry-ins to the study, whose observed breast cancer risk does not start until they join the family.

Source

Authors of the study

References

Epidemiologic and genetic follow-up study of 544 Minnesota breast cancer families: design and methods. Sellers TA, Anderson VE, Potter JD, Bartow SA, Chen PL, Everson L, King RA, Kuni CC, Kushi LH, McGovern PG, et al. Genetic Epidemiology, 1995; 12(4):417-29.

Evaluation of familial clustering of breast and prostate cancer in the Minnesota Breast Cancer Family Study. Grabrick DM, Cerhan JR, Vierkant RA, Therneau TM, Cheville JC, Tindall DJ, Sellers TA. Cancer Detect Prev. 2003; 27(1):30-6.

Risk of breast cancer with oral contraceptive use in women with a family history of breast cancer. Grabrick DM, Hartmann LC, Cerhan JR, Vierkant RA, Therneau TM, Vachon CM, Olson JE, Couch FJ, Anderson KE, Pankratz VS, Sellers TA. JAMA. 2000; 284(14):1791-8.

Examples

data(minnbreast)
breastped <- with(minnbreast, pedigree(id, fatherid, motherid, sex,
                  status=(cancer& !is.na(cancer)), affected=proband,
                   famid=famid))
plot(breastped["8"])  #plot family 8, proband is solid, slash for cancers
#Note that breastped[8] is a different family, since ids are not 1,2,3,...

Results