R: Bronchiolitis obliterans syndrome after lung transplants
bos
R Documentation
Bronchiolitis obliterans syndrome after lung transplants
Description
A dataset containing histories of bronchiolitis obliterans syndrome
(BOS) from lung transplant recipients. BOS is a chronic decline
in lung function, often observed after lung transplantation.
The condition is classified into four stages of severity: none, mild, moderate
and severe.
Usage
bos
Format
A data frame containing 638 rows, grouped by patient, including histories of 204 patients.
The first observation for each patient is defined to be stage 1, no
BOS, at six months after transplant. Subsequent observations denote
the entry times into stages 2, 3, 4, representing mild, moderate and
severe BOS respectively, and stage 5, representing death.
ptnum
(numeric)
Patient identification number
time
(numeric)
Months after transplant
state
(numeric)
BOS state entered at this time
Details
The entry time of each patient into each stage of BOS was estimated
by clinicians, based on their history of lung function measurements
and acute rejection and infection episodes. BOS is only assumed to occur
beyond six months after transplant. In the first six months
the function of each patient's new lung stabilises. Subsequently BOS
is diagnosed by comparing the lung function against the "baseline" value.
The objects bos3 and bos4 contain the same data, but
with mild/moderate/severe combined, and moderate/severe combined,
to give 3 and 4-state representations respectively.
Source
Papworth Hospital, U.K.
References
Heng. D. et al. (1998). Bronchiolitis Obliterans Syndrome: Incidence,
Natural History, Prognosis, and Risk Factors. Journal of Heart and Lung
Transplantation 17(12)1255–1263.