Extracted data from a french population based cohort (Three-City cohort). The dataset includes followup information on dementia outcome and predicted 5-year risks based on based on the subject specific information which includes age, gender, education level and cognitive decline measured by a psychometric test (Mini Mental State Examination). The prediction model from which the predictions have been computed has been fitted on independent training data from the Paquid cohort, another french population based cohort with similar design (see Reference Blanche et al. 2015 for details) .
PBC3 was a multi-centre randomized clinical trial conducted in six European hospitals. Between 1 Jan. 1983 and 1 Jan. 1987, 349 patients with the liver disease primary biliary cirrhosis (PBC) were randomized to either treatment with Cyclosporin A (CyA, 176 patients) or placebo (173 patients). The purpose of the trial was to study the effect of treatment on the survival time. However, during the course of the trial an increased use of liver transplantation for patients with this disease made the investigators redefine the main response variable to be time to “failure of medical treatment” defined as either death or liver transplantation. Patients were then followed from randomization until treatment failure, drop-out or 1 Jan, 1989; 61 patients died (CyA: 30, placebo: 31), another 29 were transplanted (CyA: 14, placebo: 15) and 4 patients were lost to follow-up before 1 Jan. 1989. At entry a number of clinical, biochemical and histological variables, including serum bilirubin, serum albumin, sex, age were recorded.
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