concordance
(Package: gespeR) :
Evaluate the concordance between Phenotype objects
Measures include the correlation (rho) between pairs of phenotypes for the same gene, the rank biased overlap (rbo) of the top and bottom of ranked lists, and the Jaccard index (J) of selected genes.
Class that represents a gespeR model. It contains a SSP Phenotypes and TargetRelations representing a siRNA knockdown experiment. When the model is fitted, it additionaly contains estimated GSP Phenotypes.
This package provides a model to deconvolute off-target confounded RNAi knockdown phentypes, and methods to investigate concordance between ranked lists of (estimated) phenotypes. The regularized linear regression model can be fitted using two different strategies. (a) Cross-validation over regularization parameters optimising the mean-squared-error of the model and (b) stability selection of covariates (genes) based on a method by Nicolai Meinshausen et al.